Molecular Formula | C17H15N5O2 |
Molar Mass | 321.33 |
Density | 1.427±0.06 g/cm3(Predicted) |
Boling Point | 641.6±65.0 °C(Predicted) |
pKa | 9.66±0.10(Predicted) |
Storage Condition | -20℃ |
In vitro study | DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.112 ml | 15.56 ml | 31.121 ml |
5 mM | 0.622 ml | 3.112 ml | 6.224 ml |
10 mM | 0.311 ml | 1.556 ml | 3.112 ml |
5 mM | 0.062 ml | 0.311 ml | 0.622 ml |
biological activity | DB07268 is a potent and selective inhibitor of JNK1 with an IC50 of 9 nM, CK2 and PLK 70-90 times. |
Target | TargetValue JNK1 (Cell-free assay) 9 nM CHK1 (Cell-free assay) 0.82 μm |
Target | Value |
JNK1 (Cell-free assay) | 9 nM |
CHK1 (Cell-free assay) | 0.82 μM |
in vitro study | DB07268 (Compound 2b), and ERK2 with IC50s of 0.82 μm, 5.5 μm, 15 μm, and 25 μm. |